N. Jeanne Wilson-Rawls, PhD

Assistant Professor - Arizona State University

UA Office Phone: (602) 827-2108
ASU Office Phone: (480) 727-6675
Office: Building 3, Room 3272
Email: norma.wilson-rawls@asu.edu

Education:

PhD; Saint Louis University School of Medicine; 1993

Research Interests:

Molecular Biology

I am interested in studying the role of the Notch signaling pathway in cell lineage decisions. The Notch signaling pathway is highly conserved from flies to mammals and it regulates the differentiation of many cell types. In my lab, we are currently studying the role of Notch signaling in folliculogenesis and gonadal development. We use a variety of approaches from biochemical assays to the study of the phenotypes of a targeted null mouse mutant of the gene lunatic fringe and tissue targeted transgenics of Notch2 mutants.

PubMed Link:

Search PubMed for a complete listing of Dr. Wilson-Rawls' publications

Selected Publications:

  1. Fischer, C., J. Johnson, B. Stillwell, Z. Cerovac, J. Conner, J. Wilson-Rawls and A. Rawls. (2004). ATF4 is required for the differentiation of the lamina propria layer of the vas deferens. Biol. Reprod. 70, 371-378.
  2. Rhee, J.M., Takahashi, Y., Saga, Y., Wilson-Rawls, J., and Rawls, A. (2003). The protocadherin papc is required for epithelialization along the segmental border during mouse somitogenesis. Dev Biol 254, 248-261
  3. Johnson, J., McGaughey, R.W., Rawls, A., Wilson-Rawls, J. (2001) Notch pathway genes are expressed in developing mammalian ovarian follicles. Mech Dev 109, 353-359
  4. Rawls, A., McGaughey, R. W., and J. Wilson-Rawls. (2001). Developmental History of the mammalian oocyte: Insight from mouse mutations. Front Biosci 6, D1173-1185.
  5. Rawls, A., Wilson-Rawls, J., and E.N. Olson. (2000). Genetic control of Somite formation. Curr. Top. Dev. Biol. 47,131-54.
  6. Wilson-Rawls, J., Molkentin, J.D., Black, B.L., and E.N. Olson. (1999). Activated notch inhibits myogenic activity of the MADS-Box transcription factor myocyte enhancer factor 2C. Mol. Cell. Biol. 19:2853-2862.
  7. Wilson-Rawls J., C. R. Hurt, S. M. Parsons and A. Rawls. (1999). Differential regulation of epaxial and hypaxial muscle formation by Paraxis. Development 126, 5217-29
  8. Wilson-Rawls, J., J. Liu, P.N. Laneuville, and R.B. Arlinghaus. 1996. P210 Bcr-Abl interacts with the interleukin-3 beta c subunit and constitutively induces its phosphorylation. Cancer Res. 56:3426-3430.
  9. L.K. Hawkins, Wilson-Rawls, J., and W.S.M. Wold. 1995. Region E3 of subgroup B human adenoviruses encode a 16,000 MW membrane protein that may be a distant analog of the E3 6.7K protein of subgroup C adenoviruses. J. Virol. 69:4292-4298.
  10. Wilson-Rawls, J., S.L. Deutscher, and W.S.M. Wold. 1994. The signal-anchor domain of adenovirus E3-6.7K, a type III integral membrane protein, can direct adenovirus E-3gp19K, a type I integral membrane protein, into the membrane of the endoplasmic reticulum. Virology 201:66-76.