Sourav Ghosh, PhD

Assistant Professor, Department of Basic Medical Sciences - The University of Arizona College of Medicine—Phoenix in partnership with Arizona State University

UA Office Phone: (602) 827-2173
Office: Building ABC1, Room 429
Email: sourav.ghosh@arizona.edu

Education:

Jane Coffin Childs Fellow and Special Fellow, Leukemia and Lymphoma Society; Salk Institute for Biological Studies, La Jolla, California; 2001-2007

PhD; University of Tennessee, Memphis, Tennessee; 2000

MS; University of Calcutta, India; 1992

Background:

Sourav Ghosh received a Master of Science degree in Zoology from the University of Calcutta. He subsequently completed his graduate work under John V. Cox, Department of Molecular Sciences at the University of Tennessee. Sourav performed his post-doctoral training in Tony Hunter’s lab at the Salk Institute of Biological Studies, before joining the faculty in August, 2007.

Research Interests:

Apical-basal polarity or asymmetry of protein distribution along the apical-basal axis within cells is a fundamental biological property

Many aspects of cell biology, such as stem cell division and differentiation, directional cell migration, axon formation, rely on proper apical-basal polarity. We are interested in the signal transduction pathways that regulate cell polarity. Our research has characterized the function of a protein kinase – atypical Protein Kinase C or aPKC – in cell adhesion and apical-basal polarity in neural stem/progenitor cells during development. Current research is focused on the comprehensive understanding of the role of aPKC signaling during organogenesis, and changes in the function of aPKC signaling pathway in tumorigenesis and invasion.

PubMed Link:

Search PubMed for a complete listing of Dr. Sourav's publications

Selected Publications:

  1. Instructive role of aPKCζ subcellular localization in the assembly of adherens junctions in neural progenitors. Sourav Ghosh, Till Marquardt, Joshua P. Thaler, Nigel Carter, Shane E. Andrews, Samuel L. Pfaff and Tony Hunter [PNAS., 2008 Jan; 105 (1):335-340].
  2. TAM receptors are pleiotropic inhibitors of the innate immune response. Carla V. Rothlin, Sourav Ghosh, Elina Zuniga, Michael Oldstone and Greg Lemke [Cell. 2007 December 14, 131: 1124-1136]
  3. Essential role of tuberous sclerosis genes TSC1 and TSC2 in NF-kappaB activation and cell survival. Sourav Ghosh, Vinay Tergaonkar, Carla V. Rothlin, Ricardo G. Correa, Virginie Bottero, Pradeep Bist, Inder M. Verma, and Tony Hunter [Cancer Cell. 2006 Sep; 10 (3):215-226]
  4. Co-expressed EphA Receptors and Ephrin-A Ligands Mediate Opposing Actions on Growth Cone Navigation from Distinct Membrane Sub-Domains. Till Marquardt, Ryuichi Shirasaki, Sourav Ghosh, Shane E. Andrews, Nigel Carter, Tony Hunter and Samuel L. Pfaff [Cell. 2005 Apr 8;121(1):127-39.]
  5. Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion. Z. Lu, Sourav Ghosh, Z. Wang and T. Hunter [Cancer Cell. 2003 Dec; 4 (6):499-515.]
  6. Mitotic regulation of ribosomal S6 kinase 1 involves Ser/Thr, Pro phosphorylation of consensus and nonconsensus sites by Cdc2. O.J. Shah, Sourav Ghosh and T. Hunter [J Biol Chem. 2003 May; 278 (18):16433-16442.]
  7. CK2 constitutively associates with and phosphorylates chicken erythroid ankyrin and regulates its ability to bind to spectrin. Sourav Ghosh, F.C. Dorsey and J.V. Cox [J Cell Science. 2002 Nov; 115:4107-4115].
  8. Dynamics of ankyrin-containing complexes in chicken embryonic erythroid cells: role of phosphorylation. Sourav Ghosh and J.V. Cox [Mol Biol Cell. 2001 Dec; 12(12):3864-3874.]
  9. Chicken Erythroid AE1 Anion Exchangers Associate with the Cytoskeleton During Recycling to the Golgi. Sourav Ghosh, K.H. Cox and J.V. Cox [Mol Biol Cell. 1999 Feb; 10(2):455-469.]